18 Nephrotic Syndrome
- may be in casts or in plasma membranes
- diseases damage podocytes leads to nephrotic syndrome
- podocytes walled off from cellular components, no inflammation, no nephritic
Minimal Change Disease
- loss of albumin (-) in urine
- HL: massive production of cytokines
- things trigger cytokines can trigger MCD
- steroids help cytokines
- most other nephrotics not responsive to steroids
- minimal changes on renal biopsy
FSGS
- more serious/dangerous version of MCD
- image: normal upright, abnormal lower left; pink deposition in abnormal
Membranous Nephropathy
- no triggering inflammation
- thick knots in string: Associated with membranous glomerulonephritis
- 3 string: Associated with membranoproliferative glomerulonephritis. Tram track appearance
- if hypercellular: membranoproliferative
Diabetic Nephropathy
Amyloidosis
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